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A Prairie Home Companion is a live radio variety show created and hosted by Garrison Keillor.

The show runs on Saturdays from 5 to 7 pm Central Time, and usually originates from the Fitzgerald Theater in Saint Paul, Minnesota, although it is frequently taken on the road.

A Prairie Home Companion is known for its musical guests, especially folk and traditional musicians, tongue-in-cheek radio drama, and Keillor's storytelling segment, " News from Lake Wobegon ".