Page "Advil" Paragraph 6

As sales increased in 1984, Whitehall Labs, the US distributor of Advil, quickly realized Boots ( the original manufacturer ) could not keep up with demand.

Boots was essentially making the product manually.

Michael Dryden of the Whitehall R & D staff was assigned to form a team and create an automated manufacturing process as soon as possible.

Dryden hired Guido Melenger, the head of a small pharma scale-up firm, to come up with an automated process.

After three years of work, a team from Whitehall concluded Melenger would be unable to complete the task and feared his company was about to go out of business.

Whitehall then formed an internal team consisting of Dryden, Webb Crew ( to develop software ) and George Van Parys Ibuprofen is normally in a crystallized form that is grown 2 times and wet granulated to form the base material.

The crystalline structure is one reason certain people can have unique reactions to the product.

The concept was first worked out between George Van Parys ( designer of the Advil manufacturing equipment ), Robert DiCianni, and Banner Pharmacaps of California in 1994.

The delay in creating the product from 1994 was in developing a method to solubilize ibuprofen without crystallization occurring inside the gelatin casing.