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Afonso was first married to his cousin Isabella of Coimbra in 1447.
Isabella died in 1455 and Afonso married again ( although not recognized by the Papacy ) in 1475, this time to Joanna of Castile ( known as " La Beltraneja "), daughter of Henry IV of Castile and Joan of Portugal.
This marriage was an attempt to inherit the throne of Castile as Joan was the sole daughter of Henry IV.
Afonso's attempts to take over the throne of Castile were not successful after he lost a short war with Isabella of Castile and Ferdinand of Aragon.

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