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The Afrotropic ecozone is home to a number of endemic plant families.
Madagascar and the Indian Ocean Islands are home to ten endemic families of flowering plants ; eight are endemic to Madagascar ( Asteropeiaceae, Didymelaceae, Didiereaceae, Kaliphoraceae, Melanophyllaceae, Physenaceae, Sarcolaenaceae, and Sphaerosepalaceae ), one to Seychelles ( Mesdusagynaceae ) and one to the Mascarene Islands ( Psiloxylaceae ).
Twelve plant families are endemic or nearly endemic to South Africa ( including Curtisiaceae, Heteropyxidaceae, Penaeaceae, Psiloxylaceae and Rhynchocalycaceae ) of which five are endemic to the Cape floristic province ( including Grubbiaceae ).
Other endemic Afrotropic families include Barbeyaceae, Montiniaceae, Myrothamnaceae and Oliniaceae.

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