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Another hypothesis is that testosterone influences brain areas that control behavioral reactions.

Studies in animal models indicate that aggression is affected by several interconnected cortical and subcortical structures within the so-called social behavior network.

A study involving lesions and electrical-chemical stimulation in rodents and cats revealed that such a neural network consists of the medial amygdala, medial hypothalamus and periaqueductal grey ( PAG ), and it positively modulates reactive aggression.

Moreover, a study done in human subjects showed that prefrontal-amygdala connectivity is modulated by endogenous testosterone during social emotional behavior.