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Several major cities exist either in the Andes or in the foothills, among which are Bogotá, Medellín and Cali, Colombia ; Quito, Ecuador ; Mérida, Venezuela ; La Paz, Bolivia ; Santiago, Chile, and Cusco, Peru.
These and most other cities and large towns are now connected with asphalt-paved roads, while smaller towns are often connected by dirt roads, which may require a four-wheel-drive vehicle.

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