Page "Androgen insensitivity syndrome" Paragraph 61
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It is theoretically possible for certain mutant androgen receptors to function without androgens ; in vitro studies have demonstrated that a mutant androgen receptor protein can induce transcription in the absence of androgen if its steroid binding domain is deleted.
Conversely, the steroid-binding domain may act to repress the AR transactivation domain, perhaps due to the AR's unliganded conformation.
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