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Beginning in late twentieth-century Japan, Angel Sanctuary focuses on Setsuna Mudo, a 16-year-old troubled high-school student who is in love with his 15-year-old sister Sara.
While struggling with his incestuous feelings for his sister, he learns that he is the reincarnation of Organic Angel Alexiel, who led a rebellion against her fellow angels after witnessing their slaughter of the Evils, a group of demons, after God's disappearance.
At the conclusion of the revolt, she sealed away her younger twin brother, Inorganic Angel Rosiel, within the Earth, emotionally unable to fulfill his request to be killed before he became insane and destructive.
Captured and branded a fallen angel, Alexiel is punished by having her body frozen and her soul endlessly reincarnated as a human whose life is full of misery.

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