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Anna Maria Luisa arranged a marriage for her younger brother at the instigation of their father: On 2 July 1697 Gian Gastone de ' Medici married Anna Maria Franziska of Saxe-Lauenburg, heiress of the eponymous duchy, in Düsseldorf.
Gian Gastone's wife repulsed him, and for that reason, they separated in 1708.

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