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As a child, Anne suffered from an eye condition, which manifested as excessive watering known as " defluxion ".
For medical treatment, she was sent to France, where she lived with her paternal grandmother, Queen Dowager Henrietta Maria, at the Château de Colombes near Paris.
Following her grandmother's death in 1669, Anne lived with an aunt, Henriette Anne, Duchess of Orléans.
On the sudden death of her aunt in 1670, Anne returned to England.
Her mother died the following year.
As was traditional in the royal family, Anne and her sister were brought up separated from their father in their own establishment at Richmond, London.
On the instructions of Charles II, they were raised as Protestants.
They were placed in the care of Colonel Edward and Lady Frances Villiers, and their education was focused on the teachings of the Anglican church.

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