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Tricyclic antidepressants are the second oldest class of antidepressant drugs.
Tricyclics block the reuptake of certain neurotransmitters such as norepinephrine and serotonin.
They are used less commonly now due to the development of more selective and safer drugs.
Side effects include increased heart rate, drowsiness, dry mouth, constipation, urinary retention, blurred vision, dizziness, confusion, and sexual dysfunction.
Toxicity occurs at about ten times normal dosages ; these drugs are often lethal in overdoses, as they may cause a fatal arrhythmia.
However, tricyclic antidepressants are still used because of their effectiveness, especially in severe cases of major depression.
Also, people who cannot tolerate the side effects of SSRIs, in particular agitation, may do better on tricyclics.
The tricyclics include:

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