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Selective serotonin reuptake inhibitors ( SSRIs ) are the class of antidepressants commonly used as the first-line treatment for depression because they have a favorable side effect profile and low toxicity.
Depression can be treated by increasing the amount of available serotonin, a chemical used in the brain to transmit signals between neurons.
SSRIs are said to work by preventing the reuptake of serotonin ( also known as 5-hydroxytryptamine, or 5-HT ) by the presynaptic neuron, thus maintaining higher levels of 5-HT in the synapse.
Chemists Klaus Schmiegel and Bryan Molloy of Eli Lilly discovered the first SSRI, fluoxetine.
This class of drugs includes:
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