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During Spider-Island she is attacked by The Sisterhood of the Wasp.
She ends up getting an unlikely ally in the Hobgoblin who then flies her to see the Kingpin.
When Spider-Girl asks why Kingpin wants her help, Kingpin reveals that he and his men have developed Spider Powers and ended up targeted by the Sisterhood of the Wasp.
He tells Spider-Girl where he has found the location of the Central Wasp Nest.
Spider-Girl refuses his help and tries enlisting the help of the Young Allies and other heroes, but they are too preoccupied with the outbreak of spider powers to help.
The new Madam Web approaches Spider-Girl and tells her that for better or for worse, she has to team up with her enemy.
As they battle against the Society of Wasps, their queen reveals that they have developed a venom to kill all spider-powered people in Manhattan.
Spider-Girl, Hobgoblin, the Kingpin, and the Hand fight against the Society of Wasps until Spider-Girl realizes what Madam Web really meant by teaming up with her enemy.
She gets everyone fighting the Wasps to temporarily assist the Wasps in fighting the spider invasion so the spiders cannot help the Queen.
This allows Spider-Man and the Avengers to defeat her without being overrun by the spiders.

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