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In 116 AD, under Trajan, it was taken over by Rome as the Roman Province of Assyria.
The Assyrians began to convert to Christianity from Ashurism during the period between the early 1st and 3rd centuries AD.
Romans and Parthians fought over Assyria and the rest of Mesopotamia until 226 AD, when it was taken over by the Sassanid ( Persian ) Empire.

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