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Exogenous substances that cause ataxia mainly do so because they have a depressant effect on central nervous system function.
The most common example is ethanol, which is capable of causing reversible cerebellar and vestibular ataxia.
Other examples include various prescription drugs ( e. g. most antiepileptic drugs have cerebellar ataxia as a possible adverse effect ), Lithium level over 1. 5mEq / L, cannabis ingestion and various other recreational drugs ( e. g. ketamine, PCP or dextromethorphan, all of which are NMDA receptor antagonists that produce a dissociative state at high doses ).
Exposure to high levels of methylmercury, through consumption of fish with high mercury concentrations, is also a known cause of ataxia and other neurological disorders.

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