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Accidental crosses were noticed as far back as 1749 in the southern English colonies of North America.
Cattle and buffalo were first intentionally crossbred during the mid-19th century.
Charles Goodnight was one of the first to succeed, and called his hybrid cattalo.
After seeing thousands of cattle die in a Kansas blizzard in 1886, Charles " Buffalo " Jones, a co-founder of Garden City, Kansas, also worked to cross buffalo and cattle at a ranch near the future Grand Canyon National Park, with the hope the animals could survive the harsh winters.
He called the result " cattalo " in 1888.
Mossom Boyd of Bobcaygeon, Ontario first started the practice in Canada.
After his death in 1914, the Canadian government continued experiments in crossbreeding up to 1964, with little success.
For example in 1936 the Canadian government had successful cross-breed 30 cattalos.
Lawrence Boyd continues the crossbreeding work of his grandfather on a farm in Alberta.

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