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Conversely beetles are prey of various invertebrates and vertebrates including insects, fish, reptiles, birds and mammals.

The Coleoptera are not generally serious pests, but they include agricultural and industrial pests, such as the Colorado potato beetle Leptinotarsa decemlineata, the boll weevil Anthonomus grandis, the red flour beetle Tribolium castaneum, and the mungbean or cowpea beetle Callosobruchus maculatus,