Page "Benzodiazepine" Paragraph 13

Benzodiazepines can be useful for short-term treatment of insomnia.

Their use beyond 2 to 4 weeks is not recommended due to the risk of dependence.

It is preferred that benzodiazepines be taken intermittently and at the lowest effective dose.

They improve sleep-related problems by shortening the time spent in bed before falling asleep, prolonging the sleep time, and, in general, reducing wakefulness.

However, they worsen sleep quality by increasing light sleep and decreasing deep sleep.

Other drawbacks of hypnotics, including benzodiazepines, are possible tolerance to their effects, rebound insomnia, and reduced slow-wave sleep and a withdrawal period typified by rebound insomnia and a prolonged period of anxiety and agitation.

The list of benzodiazepines approved for the treatment of insomnia is fairly similar among most countries, but which benzodiazepines are officially designated as first-line hypnotics prescribed for the treatment of insomnia can vary distinctly between countries.

Longer-acting benzodiazepines such as nitrazepam and diazepam have residual effects that may persist into the next day and are, in general, not recommended.