Page "Benzodiazepine" Paragraph 14
It is not clear as to whether the new nonbenzodiazepine hypnotics ( Z-drugs ) are better than the short-acting benzodiazepines.
According to the US Agency for Healthcare Research and Quality, indirect comparison indicates that side-effects from benzodiazepines may be about twice as frequent as from nonbenzodiazepines.
However, the UK National Institute for Health and Clinical Excellence did not find any convincing evidence in favor of Z-drugs.
NICE review pointed out that short-acting Z-drugs were inappropriately compared in clinical trials with long-acting benzodiazepines.
There have been no trials comparing short-acting Z-drugs with appropriate doses of short-acting benzodiazepines.