Page "Benzodiazepine" Paragraph 42

Nonbenzodiazepines are contraindicated during benzodiazepine withdrawal as they are cross tolerant with benzodiazepines and can induce dependence.

Alcohol is also cross tolerant with benzodiazepines and more toxic and thus caution is needed to avoid replacing one dependence with another.

During withdrawal, fluoroquinolone-based antibiotics are best avoided if possible ; they displace benzodiazepines from their binding site and reduce GABA function and, thus, may aggravate withdrawal symptoms.

Antipsychotics are not recommended for benzodiazepine withdrawal ( or other CNS depressant withdrawal states ) especially clozapine, olanzapine or low potency phenothiazines e. g. chlorpromazine as they lower the seizure threshold and can worsen withdrawal effects ; if used extreme caution is required.