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Biostatistical reasoning and modeling were of critical importance to the foundation theories of modern biology.
In the early 1900s, after the rediscovery of Mendel's work, the gaps in understanding between genetics and evolutionary Darwinism led to vigorous debate among biometricians, such as Walter Weldon and Karl Pearson, and Mendelians, such as Charles Davenport, William Bateson and Wilhelm Johannsen.
By the 1930s, statisticians and models built on statistical reasoning had helped to resolve these differences and to produce the neo-Darwinian modern evolutionary synthesis.

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