Page "Bipolar disorder" Paragraph 24
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According to the " kindling " hypothesis, when people who are genetically predisposed toward bipolar disorder experience stressful events, the stress threshold at which mood changes occur becomes progressively lower, until the episodes eventually start ( and recur ) spontaneously.
There is evidence of hypothalamic-pituitary-adrenal axis ( HPA axis ) abnormalities in bipolar disorder due to stress.
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