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While the central chemoreceptors in the brainstem are highly sensitive to CO < sub > 2 </ sub > the carotid body is a peripheral chemoreceptor that mainly provides afferent input to the respiratory center that is highly O < sub > 2 </ sub > dependent.
However, the carotid body also senses increases in CO < sub > 2 </ sub > partial pressure and decreases in arterial pH, but to a lesser degree than for O < sub > 2 </ sub >

2.101 seconds.