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Most chemotherapy is delivered intravenously, although a number of agents can be administered orally ( e. g., melphalan, busulfan, capecitabine ).

In some cases, isolated limb perfusion ( often used in melanoma ), or isolated infusion of chemotherapy into the liver or the lung have been used.

The main purpose of these approaches is to deliver a very high dose of chemotherapy to tumour sites without causing overwhelming systemic damage.