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Water insoluble chromium ( III ) compounds and chromium metal are not considered a health hazard, while the toxicity and carcinogenic properties of chromium ( VI ) have been known for a long time.
Because of the specific transport mechanisms, only limited amounts of chromium ( III ) enter the cells.
Several in vitro studies indicated that high concentrations of chromium ( III ) in the cell can lead to DNA damage.
Acute oral toxicity ranges between 1. 5 and 3. 3 mg / kg.
The proposed beneficial effects of chromium ( III ) and the use as dietary supplements yielded some controversial results, but recent reviews suggest that moderate uptake of chromium ( III ) through dietary supplements poses no risk.

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