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The chamber is cooled, typically with liquid nitrogen, usually to a temperature of — although temperatures of or even have been used.
The patient is protected from acute frostbite with socks, gloves and mouth and ear protection, but in addition to that, wears nothing but a bathing suit.
The patient spends a few minutes in the chamber.
During treatment the average skin temperature drops to, while the coldest skin temperature can be.
The core body temperature remains unchanged during the treatment, however it may drop slightly afterwards.
Therapy triggers the release of endorphins which induce analgesia ( immediate pain relief ).

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