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In 2008 Cronenberg realized two extra-cinematographic projects: the exhibition Chromosomes at the Rome Film Fest and the opera The Fly at the LaOpera in Los Angeles and Theatre Châtelet in Paris.
In July 2010, Cronenberg completed production on A Dangerous Method, an adaptation of Christopher Hampton's play The Talking Cure, starring Keira Knightley, Michael Fassbender, and frequent collaborator Viggo Mortensen.
The film was produced by independent British producer Jeremy Thomas.

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