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Cronenberg has collaborated with composer Howard Shore on all of his films since The Brood ( 1979 ), ( see List of noted film director and composer collaborations ) with the exception of The Dead Zone ( 1983 ), which was scored by Michael Kamen.

Other regular collaborators include actor Robert Silverman, art director Carol Spier, sound editor Bryan Day, film editor Ronald Sanders, his sister, costume designer Denise Cronenberg, and, from 1979 until 1988, cinematographer Mark Irwin.

In 2008, Cronenberg directed Howard Shore's first opera, The Fly.