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Mirkin started out as a stand-up comedian in 1982 and performed across the United States, including at The Comedy Store, where he became a regular, and at The Improv.
The first joke he used in his routine was, " Is it just me or has everybody been coughing up blood lately?
" Mirkin considers the joke to be " an insight into the way writes.
" Stand-up comedy was the most profitable and easily accessible route Mirkin found into the comedy industry, but " it wasn't a lifestyle that particularly coveted ," especially due to the traveling required.

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