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There is evidence of chemical pollutants causing frog developmental deformities ( extra limbs, or malformed eyes ).< ref > Pollutants have varying effects on frogs.
Some alter the central nervous system ; others like atrazine cause a disruption in the production and secretion of hormones.
Experimental studies have also shown that exposure to commonly used herbicides such as glyphosate ( Tradename Roundup ) or insecticides such as malathion or carbaryl greatly increase mortality of tadpoles.
Additional studies have indicated that terrestrial adult stages of amphibians are also susceptible to non-active ingredients in Roundup, particularly POEA, which is a surfactant.
Atrazine has been shown to cause male tadpoles of African clawed frogs to become hermaphroditic with development of both male and female organs.
Such feminization has been reported in many parts of the world.
In a study conducted in a laboratory at Uppsala University in Sweden, more than 50 % of frogs exposed to levels of estrogen-like pollutants existing in natural bodies of water in Europe and the United States became females.
Tadpoles exposed even to the weakest concentration of estrogen were twice as likely to become females while almost all of the control group given the heaviest dose became female.

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