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In 2010, the channel launched its first original sitcom intentionally targeted at family audiences: Good Luck Charlie, starring Bridgit Mendler and Jason Dolley.

Later in 2010, the channel also premiered the new animated series Fish Hooks, and the buddy sitcom Shake It Up.

2010 also saw the premieres of four original movies: Starstruck, Den Brother, Camp Rock 2: The Final Jam and Avalon High.

Two other made-for-TV movies produced for Disney Channel in association with Canadian specialty cable channels debuted as well ( Harriet the Spy: Blog Wars, produced in association with pay services Movie Central and The Movie Network ; and 16 Wishes, produced in association with Family Channel ).