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Paracelsus ( 1491 – 1541 ) developed the concept and published it in his writings.

During the first half of the 16th century, Paracelsus traveled throughout Europe and to the Levant and Egypt, treating people and experimenting with new plants in search of more treatments and solutions.

As a professor of medicine at the University of Basel, he dramatically burned classical medical texts by Theophrastus, Galen, Dioscorides and Avicenna, but not the works of Hippocrates.