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In 2007, he was featured in an advertising campaign for Australian telecommunications company Telstra's Next G network, appeared in the 50 Cent video " Follow My Lead " as a psychiatrist, and played the title character in the family film Mr. Magorium's Wonder Emporium.

In 2008, although he was reluctant to perform in an animated film, Hoffman had a prominent role as Shifu in the acclaimed film Kung Fu Panda, which was praised in part for his comedic chemistry with Jack Black ( whom he tutored in acting for an important scene ) and his character's poignantly complex relationship with the story's villain.

He later won the Annie Award for Voice Acting in an Animated Feature for Kung Fu Panda and has continued into the role in the franchise's subsequent filmed productions outside of the franchise's television series.

He next voiced Roscuro in The Tale of Despereaux and played the title character in Last Chance Harvey.