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Kyle, who is Jewish, is often the target of Cartman's slander and anti-Semitic insults.

The two have shared an enmity since the show's beginnings, and their rivalry has become significantly more pronounced as the series has progressed, with Cartman even routinely exposing Kyle to physical endangerment.

Although, at other times, Kyle is an enthusiastic participant in Cartman's schemes and Cartman is sometimes seen actually being nice to Kyle in some instances.

Parker and Stone have compared the relationship to the one shared by Archie Bunker and Michael " Meathead " Stivic on the 1970s sitcom All in the Family.

Kyle has a tendency to make what he thinks are safe bets with Cartman, and often loses these bets when the improbable actions promised by Cartman are accomplished.

Cartman's motivation in this regard is not merely monetary gain, but an obsession with scoring a victory over Kyle, a fixation that ultimately plays a major part in a subplot to the three-part episode " Imaginationland " ( season 11, 2007 ).

In " You're Getting Old ," the final episode of the first half of South Park's 15th season, it is hinted that Kyle and Cartman may be developing a genuine friendship, possibly due to the void left by Stan's apparent departure.

Cartman's resentment of Stan is usually reserved for when Cartman proudly proclaims his hatred for both Stan and Kyle as a duo, and his contempt for Stan as an individual is usually limited to his annoyance with Stan's sensitivity, affection for animals, and the relationship Stan shares with Wendy.