Page "Final Fantasy VII: Advent Children" Paragraph 3

Two years have passed since the eventual defeat of Sephiroth at the hands of Cloud Strife.

Since then, Cloud has been living with his childhood friend Tifa Lockhart in a city called Edge, built on the outskirts of the Planet's former capital, Midgar.

Together, they have been taking care of Marlene ( their friend Barret Wallace's daughter ), and the orphan Denzel, who Cloud met outside a church in the slums of Midgar.

Cloud and many other citizens have become infected by a strange disease known as " Geostigma ", the origins of which are unknown, and for which there is no known cure.