Page "Folding@home" Paragraph 7

In 2002, Folding @ home used Markov state models to complete approximately a million CPU days of simulations over the span of several months, and in 2011, MSMs parallelized another simulation that required an aggregate 10 million CPU hours of computation.

In January 2010, Folding @ home used MSMs to simulate the dynamics of the slow-folding 32-residue NTL9 protein out to 1. 52 milliseconds, a timescale consistent with experimental folding rate predictions but a thousand times longer than previously achieved.

The model consisted of many individual trajectories, each two orders of magnitude shorter, and provided an unprecedented level of detail into the protein's energy landscape.

In 2010, Folding @ home researcher Greg Bowman was awarded the Thomas Kuhn Paradigm Shift Award from the American Chemical Society for the instrumental development of the open-source MSMBuilder software and for attaining quantitative agreement between theory and experiment.

For his work, Pande was awarded the 2012 Michael and Kate Bárány Award for Young Investigators for " developing field-defining and field-changing computational methods to produce leading theoretical models for protein and RNA folding " as well as the 2006 Irving Sigal Young Investigator Award for his simulation results which " have stimulated a re-examination of the meaning of both ensemble and single-molecule measurements, making Dr. Pande ’ s efforts pioneering contributions to simulation methodology.