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Fort Ancient is a name for a Native American culture that flourished from 1000-1750 CE among a people who predominantly inhabited land along the Ohio River in areas of modern-day southern Ohio, northern Kentucky, southeastern Indiana and western West Virginia.

They were a maize-based agricultural society who lived in sedentary villages and built ceremonial platform mounds.

The Fort Ancient culture was once thought to have been an expansion of the Mississippian cultures.

It is now accepted as an independently developed culture that descended from the Hopewell culture ( 100 BCE – 500 CE ).