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Genoa was able to stabilize its position as it moved into the sixteenth century, particularly thanks to the efforts of Andrea Doria, who established a new constitution in 1528, making Genoa a satellite of the Spanish Empire.
Under the ensuing economic recovery, many aristocratic Genoese families, such as the Balbi, Doria, Grimaldi, Pallavicini, and Serra, amassed tremendous fortunes.
According to Felipe Fernandez-Armesto and others, the practices Genoa developed in the Mediterranean ( such as chattel slavery ) were crucial in the exploration and exploitation of the New World.
Christopher Columbus, for example, was a native of Genoa and donated one-tenth of his income from the discovery of the Americas for Spain to the Bank of Saint George in Genoa for the relief of taxation on foods.

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