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While Büchner continued his studies in Gießen he established a secret society dedicated to the revolutionary cause.
With the help of the evangelical theologian Friedrich Ludwig Weidig, he published the leaflet Der Hessische Landbote, a revolutionary pamphlet criticizing social grievances in the Grand Duchy of Hesse.
The authorities charged them with treason and issued a warrant of apprehension.
While Weidig was arrested, tortured and died imprisoned in Darmstadt, Büchner fled across the border to Strasbourg where he wrote most of his literary work and translated two plays by Victor Hugo, Lucrèce Borgia and Marie Tudor.
Two years later, his dissertation, " Mémoire sur le Système Nerveux du Barbeaux ( Cyprinus barbus L .)" was published in Paris and Strasbourg.
He was influenced by the utopian communist theories of François-Noël Babeuf and Claude Henri de Saint-Simon.
In October 1836, after receiving his doctorate and being appointed by the University of Zurich as a lecturer in anatomy, Büchner relocated to Zurich where he spent his final months writing and teaching until he died of typhus at the age of twenty-three.

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