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George Frederick of Brandenburg-Ansbach () ( April 5, 1539, Ansbach – April 25, 1603 ) was Margrave of Ansbach and Bayreuth, as well as Regent of Prussia.

He was the son of George, Margrave of Brandenburg-Ansbach and a member of the House of Hohenzollern.

First ( 1559 ) he married Elisabeth of Brandenburg-Küstrin ( 29 August 1540 – 8 March 1578 ).

He secondly married ( 1579 ) Sophie of Brunswick-Lüneburg ( October 30, 1563 – 1639 ), daughter of William of Brunswick-Lüneburg and Dorothea of Denmark.