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In presenting the Nobel Prize in Physiology or Medicine in 1934, Professor I. Holmgren of the Nobel committee observed that " Of the three prize winners, it was Whipple who first occupied himself with the investigations for which the prize is now awarded.
... Whipple's experiments were planned exceedingly well, and carried out very accurately, and consequently their results can lay claim to absolute reliability.
These investigations and results of Whipple's gave Minot and Murphy the idea that an experiment could be made to see whether favorable results might also be obtained in the case of pernicious anemia ... by making use of the foods of the kind that Whipple had found to yield favorable results in his experiments regarding anemia from loss of blood.

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