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He was born in Florence.
His father Francesco Giamberti was a woodworker and architect, much employed by Cosimo de Medici, and his brother Antonio da Sangallo the Elder and nephew Antonio da Sangallo the Younger were architects.
His son Francesco da Sangallo was a sculptor.
Giuliano was the preferred architect of Lorenzo de ' Medici, so a significant number of his commissions came from the Medici.

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