Page "Gumma (pathology)" Paragraph 3

These central regions begin to die through coagulative necrosis, though they also retain some of the structural characteristics of previously normal tissues, enabling a distinction from the granulomas of tuberculosis where caseous necrosis obliterates preexisting structures.

Other histological features of gummas include an intervening zone containing epithelioid cells with indistinct borders and multinucleated giant cells, and a peripheral zone of fibroblasts and capillaries.

Inflitration of lymphocytes and plasma cells can be seen in the peripheral zone as well.

With time, gummas eventually undergo fibrous degeneration, leaving behind an irregular scar or a round fibrous nodule.