Page "HFE hereditary haemochromatosis" Paragraph 38

Serum transferrin and transferrin saturation are commonly used as screening for haemochromatosis.

Transferrin binds iron and is responsible for iron transport in the blood.

Measuring transferrin provides a crude measure of iron stores in the body.

Fasting transferrin saturation values in excess of 45 % ( or 35 % in premenopausal women ) are recognized as a threshold for further evaluation of haemochromatosis.

Transferrin saturation greater than 62 % is suggestive of homozygosity for mutations in the HFE gene.