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After receiving her PhD in 1950, Newcombe never worked full-time as a chemist, due in large part to the fact that, at that time, married women with children were not expected to work.
Daughter Nora was born in 1951 and son George in 1953, both in Toronto, where Alan was working at the Ontario Research Foundation.
In 1955, the Newcombes moved to the Hamilton area of southern Ontario, where Alan took a job as Director of Research and Development for Porritts & Spencer, a manufacturer of felts for paper making.
Son Ian was born in 1956.
While raising her three children, Newcombe worked occasionally as an instructor in chemistry.
She also took advantage of her knowledge of several languages, including Czech, German and English, to translate scientific articles.
In 1962, she briefly tried teaching high school chemistry, but was dismayed by her students ' lack of interest in her subject.

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