Page "Haptoglobin" Paragraph 0
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In blood plasma, haptoglobin binds free hemoglobin ( Hb ) released from erythrocytes with high affinity and thereby inhibits its oxidative activity.
The haptoglobin-hemoglobin complex will then be removed by the reticuloendothelial system ( mostly the spleen ).
In intravascular hemolysis free hemoglobin will be released into circulation and hence haptoglobin will bind the Hb.
Conversely, in extravascular hemolysis the reticuloendothelial system, especially splenic monocytes, phagocytose the erythrocytes and hemoglobin is not released into circulation ; serum haptoglobin levels are therefore normal.
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