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Following the outbreak of World War I he joined the Royal Army Medical Corps.
Initially posted to Wimereux, near Boulogne, he acted as medical minder to a French-American dentist, Valadier, who was not allowed to operate unsupervised but was attempting to develop jaw repair work.
Gillies, eager after seeing Valadier experimenting with nascent skin graft techniques, then decided to leave for Paris, to meet the renowned surgeon Hippolyte Morestin.
He saw him remove a tumour on a patient's face, and cover it with jaw skin taken from the patient.
Gillies became enthusiastic about the work and on his return to England persuaded the army's chief surgeon, Arbuthnot-Lane, that a facial injury ward should be established at the Cambridge Military Hospital, Aldershot.

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