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Hatshepsut died as she was approaching what we would consider middle age given typical contemporary lifespans, in her twenty-second regnal year.
The precise date of Hatshepsut's death — and the time when Thutmose III became the next pharaoh of Egypt — is considered to be Year 22, II Peret day 10 of her reign, as recorded on a single stela erected at Armant or January 16, 1458 BC.
This information validates the basic reliability of Manetho's kinglist records since Hatshepsut's known accession date was I Shemu day 4, ( i. e.: Hatshepsut died 9 months into her 22nd year as king, as Manetho writes in his Epitome for a reign of 21 years and 9 months ).
No contemporary mention of the cause of her death has survived.
If the recent identification of her mummy ( see below ) is correct, however, the medical evidence would indicate that she suffered from diabetes and died from bone cancer which had spread throughout her body while she was in her fifties.
It also would suggest that she had arthritis and bad teeth.

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