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Pomeroy & Company was succeeded in 1844 by Livingston, Wells & Company, composed of Crawford Livingston, Henry Wells, William Fargo and Thaddeus Pomeroy.
On April 1, 1845, Wells & Company's Western Express – generally known simply as Western Express because it was the first such company west of Buffalo, New York – was established by Wells, Fargo and Daniel Dunning.
Service was offered at first as far as Detroit, rapidly expanding to Chicago, St. Louis, and Cincinnati.

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