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Lange returned to television for a 1966 role in the series The Fugitive ( 1963 ).

She starred from 1968 to 1970 in the popular television series, The Ghost & Mrs. Muir for which she earned two Emmy Awards and a Golden Globe Award nomination.

This success was followed by three seasons on The New Dick Van Dyke Show as Dick Van Dyke's wife, Jenny Preston, from 1971 to 1974, declining to return for a fourth season of the show.

She also appeared in twelve television movies.

In 1977, she returned to the Broadway stage where her acting career had originally begun.

She also played the wife of Charles Bronson in the original Death Wish film.

In 1985, she appeared in A Nightmare on Elm Street 2: Freddy's Revenge and in 1986, she took a role as Laura Dern's mother in David Lynch's Blue Velvet.

She took a Broadway role in Same Time, Next Year and then made appearances in the television movie based on Danielle Steel's Message from Nam and in 1994's Clear and Present Danger.